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Cheesy Cajun Garlic Chicken Rotini Skillet Recipe

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This Cheesy Cajun Garlic Chicken Rotini Skillet is a creamy, comforting one-pan meal with tender chicken, a rich cheese sauce, and bold Cajun flavors. Perfect for a quick weeknight dinner or a crowd-pleasing dish, it combines simplicity with indulgence.

  • Total Time: 30 minutes
  • Yield: 4 servings 1x

Ingredients

Scale
  • 2 boneless, skinless chicken breasts, cut into bite-sized chunks

  • 12 oz rotini pasta

  • 2 tablespoons olive oil

  • 2 tablespoons Cajun seasoning

  • 1 teaspoon garlic powder

  • 1/2 teaspoon onion powder

  • Salt and pepper, to taste

  • 4 cloves garlic, minced

  • 1 tablespoon butter

  • 1 cup heavy cream

  • 1/2 cup chicken broth

  • 1 cup shredded mozzarella cheese

  • 1/2 cup grated Parmesan cheese

  • 1/2 cup shredded cheddar cheese

  • Fresh parsley, chopped (for garnish)

Instructions

  • Bring a large pot of salted water to a boil. Cook rotini until al dente, drain, and set aside.

  • Cut chicken into bite-sized pieces. Toss with Cajun seasoning, garlic powder, onion powder, salt, and pepper.

  • Heat olive oil in a large skillet over medium-high heat. Cook chicken for 6–7 minutes until browned and fully cooked. Remove from skillet.

  • Melt butter in the same skillet. Sauté minced garlic for 1 minute.

  • Pour in chicken broth and heavy cream. Bring to a gentle simmer.

  • Stir in mozzarella, Parmesan, and cheddar cheeses until smooth.

  • Add cooked rotini and chicken back to the skillet. Toss to coat evenly. Simmer 2–3 minutes.

  • Garnish with fresh parsley and extra cheese if desired. Serve hot

Notes

  • Customize with vegetables like bell peppers, mushrooms, or spinach.

  • Adjust Cajun seasoning to taste for mild or spicy flavor.

  • For a lighter version, substitute half-and-half for heavy cream.

  • Author: Layla
  • Prep Time: 10 minutes
  • Cook Time: 20 minutes